Evidence for Change

In our Evidence for Change series, we provide a brief overview of key behavioral science research that Atlantis Health applies in supporting patients living with long-term conditions to achieve optimal health outcomes and Change for Good.

 

Research selected

"Medication non-adherence: Reflecting on two decades since WHO adherence report and setting goals for the next twenty years" Kardas, P., Bennett, B., Borah, B., Burnier, M., Daly, C., Hiligsmann, M., Menditto, E., Peterson, A. M., Slejko, J. F., Tóth, K., Unni, E., & Ágh, T. (2024). Frontiers in Pharmacology, 15, 1444012.

Relevance today

Challenge: Medication nonadherence represents a critical healthcare challenge where patients do not follow prescribed treatment protocols.

This widespread issue significantly impacts patient health outcomes, with up to 77% of multimorbid patients failing to adhere to their medication regimens.

The consequences are substantial, including increased healthcare utilization and medical costs, as well as compromised treatment effectiveness.

Nonadherence is often unintentional, but solutions aimed at addressing forgetting and other practical barriers have not improved nonadherence rates. Intentional nonadherence—driven by various factors such as patient perceptions and motivations, medication side effects, a lack of understanding of the condition and associated treatment plan, among others—also requires attention. 

Both types of nonadherence need to be addressed through innovative strategies that focus beyond patient education to improve treatment adherence and overall patient care.

What the research tells us

A panel of 10 international experts across Europe and the United States collaborated to:

  1. Identify the 10 most significant achievements in medication adherence management over the past 20 years
  2. Delineate the 10 future targets for medication adherence management over the next 20 years

The key message is that medication nonadherence is multifaceted with no single, simple answer. Interdisciplinary collaboration and a holistic approach will be key to addressing medication nonadherence in the decades to come, especially with the fields of behavioral science and health psychology

Top 10 medication adherence targets

Patient

  • Improving patient education to enhance understanding of illness and medications 
  • Incorporating medication adherence as a standard measure in routine clinical practice 

Condition

  • Developing and implementing new technologies to support adherence and persistence that directly target pathogenic mechanisms contributing to disease development and progression 
  • Identifying risk of nonadherence in clinical practice for early intervention 

Therapy

  • Advancing the role of digital technology targeting improved adherence 
  • Managing adherence in the context of polypharmacy and multimorbidity

Social & economic

  • Implementing comprehensive measures of medication adherence that establish a stronger connection between adherence and health outcomes
  • Further examination of the wider financial and social implications of medication adherence 

Healthcare system

  • Leveraging AI in adherence management
  • Increasing access to adherence-enhancing interventions via expansion of reimbursement and insurance coverage 
To respond to adherence challenges successfully, it is crucial to harness advancements in behavioral sciences and health psychology.

Applying the research

At Atlantis Health, we specialize in behavioral science and health psychology to develop personalized and holistic patient support solutions that ensure effective patient engagement and adherence. 

Working with pharmaceutical companies, biotech and healthcare organizations, we improve patient experiences and outcomes.

Read more about our services and our co-designed digital health solutions.